I use 42-09 gauge strings on my other guitars, and 46-10 gauge strings on my LP Studio, I found that I can make the transition from 42-09 gauge to 46-10 gauge fairly easily cause the 24 3/4 inch scale length of my LP Studio means that the string tension is about the same so it's relatively easy to adapt.
Is it just my imagination or does the 14:1 gear ratio of the Grover Kluson Deluxe tuners, on my LP Studio, seem suit the 46-10 gauge strings better?, I don't know.
I've noticed that tuners with an 18:1 Gear Ratio seem to suit 42-09 gauge strings and tuners with a 14:1 Gear ratio seem to suit 46-10 gauge strings, you wouldn't think that the gear ratio of a tuner would suit particular string gauges but that's something I've observed.
I know that the higher the gear ratio of the tuner the finer/more accurate the tuning is, so therefore tuners like the Steinberger Gearless Tuners with the supposedly 40:1 ratio should be very accurate in terms of tuning.