It sounds to me like either a physical issue with the USB ports, cabling, or motherboard in the laptop, or a driver issue. In either case, examining the data stream over USB won't get you any closer to a fix. Maybe it could help identify whether it's a USB power issue or not.

Is the 2i2 powered from the USB cable, or separately? If powered by a separate supply you could try running a data-only USB cable to rule out noisy power from the USB port. Another thing to try is putting a powered USB hub in between the laptop and 2i2. That might help isolate noisy power from the laptop USB port. It might also make no difference