Yes mate, they sound very different. I've only finished the ES-1G (then refinished it) - still going on my PRS-1H. I put Tonerider humbucker sized P90's in the ES-1G but I think I will wind some proper PAF humbuckers as that's my preference. I think you get more of a raw throatier sound in the neck pickup with the semi-hollowbodies and the bridge is a bit edgier IMHO. The vibration of the semi-hollow body definitely feeds into the microphonics of the pickup to create that unique sound!