It's very easy to stick with what you know, but then you do get very similar sounding guitars. But if you go too far off your known path, you can then become very disappointed, or end up with a guitar that's only good for one particular sound - and it may be a sound that you'd never actually use in anger.
And all those multi-configuration pickup switching options often give you a couple of extra useable tones, and the rest are normally very thin or phasey and tones you are unlikely to use unless creating an experimental music album.
Of the 21 combinations available on my Jimmy Page model Les Paul, I only use 7.