I think ideally I would have two boosts, one at either side of the drive pedals. I might build another one to put at the front.
It's the same with compressors. I have an always on compressor set for very light compression - the forget it's there until it's turned off settings - placed near the very end of the effects chain. It's really just for a bit of volume limiting on very high volume transients and for evening out the volume levels from fingerpicked passages. Since I built the Lemon Squeezy (Orange Squeezer clone) I have placed it just after the buffer, in front of the drive pedals. While I like the sound, it does restrict the picking dynamics of the drive pedals.
On my next board shuffle I might try moving the lemon squeezy to after the dirt pedals.