The Strat 'quack' is reliant on the pickup spacing. The three pickups on a Strat are closer together than the two pickups on say a Tele, so a Tele won't give you quite the same sound and less 'quack' in the middle position as positions 2 and 4 on a Strat do. You can obviously position two pickups closer together to get a similar 'quack', but then you compromise the single pickup sounds, either less bright if you move the bridge pickup forwards, or less depth and bass if you move the neck pickup back. Or a bit of both if you move them both together a bit.

Bridge humbucker orientation won't make that much difference to the sound as you can select, via the wiring, which humbucker coil is used for the split sound. The slug coil will sound a tiny bit more like a Fender single coil than the screw coil, but not a lot. Probably more difference in sound due to the screw poles being higher (so closer to the strings) than the slug poles.

What style of guitar body will this be going in? Trying to fit fairly complicated wiring solutions into a Tele control cavity can be 'interesting'.