In my opinion, Strats are played out. They are iconic, yes, but they have been done to death. Most people who like strats have one or more already.
I would like to see something a bit more original. Still classic, just not bog standard. If you want a guitar with "WOW" factor, I think a standard looking strat is the wrong move. And giving it a mahogany neck, ebony fretboard and flashy pickguard is not going to set it apart from the millions of others out there.
My initial thought would be to stick with the basic strat shape and think a little outside the box, more along the lines of a Suhr:
or a Mayones:
Both of these retain that classic look, but with an edge.