Very subjective topic this one and it really comes down to which era and also which genre?
For me late 60's to early 70's was mostly dominated by the Brits such as Page, Blackmore, Townsend, Clapton, Lennon, McCartney, John Paul Jones, Dave Gilmour, Roger Waters, with Hendrix the only decent Yank I can remember around this period.
70's and 80's was a weird time moving through disco, west coast sound, punk and then on to new wave however stand outs through all of this in my opinion were mostly Aussies such as the Young Brothers in AC/DC, Brewsters in Angels, Mossy in Chisel and as far as overseas acts went Knopfler arrived on the scene and I was just discovering a 3 piece Canadian band called Rush who at this time were judged the best musicians in the world for their respective instruments. Almost forgot Gary Moore who had a killer thick bluesy tone .
80's - 90's - to now has seen plenty of American R & B, Hip Hop, Rap stuff that doesn't get me going and is also totally devoid of much axe playing. Grunge arrived and from the ashes of Nirvana emerged an even better band with Dave Grohl out front of Foo Fighters. Not much tricky stuff going on but he knows how to write tuneful songs in much the same way as McCartney does with all band members contributing to an overall complete sound. For mine during this period Slash stands out and he has only got better over past couple of solo albums compared to his high points with Gunners. Muse have also arrived on the scene and whilst not everyone's cup of tea you cannot deny their talent and unique sound. Chillis have contributed plenty of good stuff too and just as well that Flea is such a good Bass player as John wasn't that strong a lead player.
If I had to pick a dream line up it would be Slash on lead, Malcolm Young on Rhythm, and Geddy Lee on Bass or Flea if he cannot make the gig.