The old Tonewood debate

Personally, from many years of this stuff I have come to the conclusion that the nicest sounding instruments are made from quarter sawn timber with a nice tap tone.
Add a well made neck and good quality hardware and electrics and you end up with a very tasty guitar.

Now I know that many will say timber etc has nothing to do with the tone but I disagree.
Slap a high end pup into a body made of, let's say for arguments sake, MDF you will get a muddy tone.
Same pup in decent timber and the whole dynamic changes.
My conclusion is that all parts must act together, ie: the material used changes the way the strings vibrate so why use rubbish and expect a great sound?

Of course there are man made materials that posses a nice tonal quality, classic example is the ubiquitous Steinberger.