I know a few people here, McCreed for certain, have added a belly cut and a forearm contour (like on a Strat). If necessary, you can also rout (or simply drill out) some chambers below the scratchplate area.

Alternatively you could simply take a few mm off the back to make a thinner body. I did this to a home-made Tele body I was given. Just measure the cavity depths first to know how much you can safely remove and still leave some wood at the bottom of the control cavity.

I've re-profiled a few necks to improve the feel. I find that the 'shoulders' of the neck, where it meets the fingerboard, play a big part in how the neck feels. Even a small change in angle here can affect how your hand gets splayed out by the neck.

I'd try and avoid taking anything much off the very back, as the truss rod channel isn't that far below the surface. Stick to the sides and you'll be fine.