It could certainly be done if you are up to doing some basic routing and filling in of holes.

If you go for a proper wide range style pickup for the neck, then that's wider than a standard humbucker, so the neck pup rout will need to be made a bit wider to suit. The bridge pickup will be a bit further back than the humbucker of the standard kit, so you'll probably need to do a mixture of filling in and routing out. The good thing is that any small mistakes will be mainly hidden by the scratchplate. I'd get a suitable scratchplate and base everything around that. Also, choosing a solid colour rather than a stain + clear will make it easier to hide any filling or joins.