Update:

Here's a couple of screenshots of Reason 10 running on my studio PC which is running Windows 10 64Bit, as you can see, it's running with no problems:

Click image for larger version.  Name: Reason 10_1_resized.jpg  Views: 367  Size: 261.7 KB  ID: 26184

Click image for larger version.  Name: Reason 10_2_resized.jpg  Views: 424  Size: 285.7 KB  ID: 26185