I'll let you know how it goes mate, how low a latency should I be able to get without crackles and pops?, I'm doing some experimenting with different buffer settings in Ableton Live using my Scarlett 2i2, so far I've got it set to 8ms and it doesn't seem to be crackling and popping.
I'm pretty sure that all the Sata HDD (four altogether) in my DAW PC are 7200rpm types.
With my Focusrite Saffire Pro 40, I was able to get the latency down to about 12ms before I started getting pops and crackles in the Audio playback, this was at a sample rate of 44,100/16Bit, I tend to have my sample rate set to 44,100/16Bit (CD Quality).