I suppose it comes down to the purpose of use that you have for the guitar. Not to sound derogatory, but if you are 'Shredding' or playing 'heavy metal' at extreme gain and heavy distortion, you probably wouldn't see any discernable difference in tone resulting from the product used to paint and seal the guitar body.
Being an acoustic builder I know how important tone is. An acoustic guitar is really an 'air pump' and the more plastic you stuff into the pores the less the guitar resonates and hence tone is dulled. I'm guessing that the same principles will surely apply to an electric...