I don't think you'll have a problem with the pickups, you might have a problem where the strings come on to the fretboard. If the spread is too wide the strings will come too close to the edge of the fretboard. You could do a mock up on a piece of paper (or three), draw a centre line, mark the width of your nut, measure scale length and plot out the spread where the bridge is gonna go. Connect the dots and you've got your string spacing.