In my humble opinion, absolutely! I have the 4x10 and the 1x15, and the 4 10 is plenty really. My amp was 200 watts and I played for years with one guitar player who kept graduating to larger amps, finishing with a 50w Marshall with 2 quad boxes, and I only needed the second cab, which takes the amp to 350w, for large rooms. Looked really cool on stage with full stack when you're 20, hurts your back to carry them both when you're fifty...
With small rooms, when I had the full rig, we would run almost all the bass straight offstage as the small PA back in the day worked better without having the bass through the front of house. One advantage of having a bigger rig, but now days decent PA systems would handle the bass easily I'd imagine.